β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial–Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

β-sitosterol (BS), a major bioactive constituent present in plants, has shown potent anti-cancer activity against many human cancer cells, but its activity in pancreatic cancer (PC) cells has rarely been reported. Gemcitabine (GEM) is one of the first-line drugs for PC therapy, however, the treatmen...

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Foilsithe in:Front Pharmacol
Main Authors: Cao, Zhang-qi, Wang, Xue-xi, Lu, Li, Xu, Jing-wen, Li, Xiao-bin, Zhang, Guang-ru, Ma, Zhan-jun, Shi, An-chen, Wang, Yan, Song, Yu-jun
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2019
Ábhair:
Pharmacology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331459/
https://ncbi.nlm.nih.gov/pubmed/30670971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01525
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