A two gene-based risk score predicts alcoholic cirrhosis development in males with at-risk alcohol consumption

BACKGROUND: Alcoholic cirrhosis represents 1% of all cause-of-deaths worldwide. Its incidence is higher in males and results from the combination of environmental and genetic factors. Among all the genetic determinants of alcoholic cirrhosis, the patatin-like phospholipase domain protein 3 (PNPLA3)...

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Vydáno v:Appl Clin Genet
Hlavní autoři: Mancina, Rosellina Margherita, Ferri, Flaminia, Farcomeni, Alessio, Molinaro, Antonio, Maffongelli, Angela, Mischitelli, Monica, Poli, Edoardo, Parlati, Lucia, Burza, Maria Antonella, De Santis, Adriano, Attilia, Fabio, Rotondo, Claudia, Rando, Maria Margherita, Attilia, Maria Luisa, Ceccanti, Mauro, Ginanni Corradini, Stefano
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2019
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330982/
https://ncbi.nlm.nih.gov/pubmed/30666147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/TACG.S187922
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