Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis

BACKGROUND: Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1...

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Vydáno v:Arthritis Res Ther
Hlavní autoři: Trellu, Sabine, Courties, Alice, Jaisson, Stéphane, Gorisse, Laëtitia, Gillery, Philippe, Kerdine-Römer, Saadia, Vaamonde-Garcia, Carlos, Houard, Xavier, Ekhirch, François-Paul, Sautet, Alain, Friguet, Bertrand, Jacques, Claire, Berenbaum, Francis, Sellam, Jérémie
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330409/
https://ncbi.nlm.nih.gov/pubmed/30635030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1801-y
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