Using tree-based methods for detection of gene–gene interactions in the presence of a polygenic signal: simulation study with application to educational attainment in the Generation Scotland Cohort Study

MOTIVATION: The genomic architecture of human complex diseases is thought to be attributable to single markers, polygenic components and epistatic components. No study has examined the ability of tree-based methods to detect epistasis in the presence of a polygenic signal. We sought to apply decisio...

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Pubblicato in:Bioinformatics
Autori principali: Meijsen, Joeri J, Rammos, Alexandros, Campbell, Archie, Hayward, Caroline, Porteous, David J, Deary, Ian J, Marioni, Riccardo E, Nicodemus, Kristin K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Original Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330004/
https://ncbi.nlm.nih.gov/pubmed/29931044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty462
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