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Crumble: reference free lossy compression of sequence quality values

MOTIVATION: The bulk of space taken up by NGS sequencing CRAM files consists of per-base quality values. Most of these are unnecessary for variant calling, offering an opportunity for space saving. RESULTS: On the Syndip test set, a 17 fold reduction in the quality storage portion of a CRAM file can...

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Dettagli Bibliografici
Pubblicato in:Bioinformatics
Autori principali: Bonfield, James K, McCarthy, Shane A, Durbin, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6330002/
https://ncbi.nlm.nih.gov/pubmed/29992288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/bty608
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