Semaphorin signaling via MICAL3 induces symmetric cell division to expand breast cancer stem-like cells

Cancer stem-like cells (CSCs) are expanded in the CSC niche by increased frequency of symmetric cell divisions at the expense of asymmetric cell divisions. The symmetric division of CSCs is important for the malignant properties of cancer; however, underlying molecular mechanisms remain largely elus...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Tominaga, Kana, Minato, Hiroshi, Murayama, Takahiko, Sasahara, Asako, Nishimura, Tatsunori, Kiyokawa, Etsuko, Kanauchi, Hajime, Shimizu, Seiichiro, Sato, Ayaka, Nishioka, Kotoe, Tsuji, Ei-ichi, Yano, Masao, Ogawa, Toshihisa, Ishii, Hideshi, Mori, Masaki, Akashi, Koichi, Okamoto, Koji, Tanabe, Masahiko, Tada, Kei-ichiro, Tojo, Arinobu, Gotoh, Noriko
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2019
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329980/
https://ncbi.nlm.nih.gov/pubmed/30587593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1806851116
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