Trabid inhibits hepatocellular carcinoma growth and metastasis by cleaving RNF8-induced K63 ubiquitination of Twist1

TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently reported to activate Wnt/ β-catenin signaling pathway. However, the role of Trabid in tumors including hepatocellular carcinoma (HCC) and the underlying mechanisms controlling its activity remain poorly understood. Here, we...

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Publicat a:Cell Death Differ
Autors principals: Zhu, Yuekun, Qu, Chao, Hong, Xuehui, Jia, Yanyan, Lin, Meihua, Luo, Yunmei, Lin, Fengqin, Xie, Xiaolong, Xie, Xiaoqi, Huang, Juan, Wu, Qin, Qiu, Xingfeng, Piao, Daxun, Xing, Yanwei, Yu, Tian, Lu, Yuanfu, Huang, Qiang, Yu, Changyin, Jin, Junfei, Zhang, Zhiyong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329825/
https://ncbi.nlm.nih.gov/pubmed/29748601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0119-2
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