Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, we develop ultrasoft mechanosensors that visibly deform under less than 10 Pascals of cell-generated stress. By incorporating these mechanosensors into multicell...

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Udgivet i:Nat Commun
Main Authors: Lee, Wontae, Kalashnikov, Nikita, Mok, Stephanie, Halaoui, Ruba, Kuzmin, Elena, Putnam, Andrew J., Takayama, Shuichi, Park, Morag, McCaffrey, Luke, Zhao, Ruogang, Leask, Richard L., Moraes, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329783/
https://ncbi.nlm.nih.gov/pubmed/30635553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07967-4
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