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Buprenorphine Maintenance Subjects Are Hyperalgesic and Have No Antinociceptive Response to a Very High Morphine Dose

OBJECTIVE: Acute pain management in opioid-dependent persons is complicated because of tolerance and opioid-induced hyperalgesia. Very high doses of morphine are ineffective in overcoming opioid-induced hyperalgesia and providing antinociception to methadone-maintained patients in an experimental se...

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Detalhes bibliográficos
Publicado no:Pain Med
Main Authors: Athanasos, Peter, Ling, Walter, Bochner, Felix, White, Jason M, Somogyi, Andrew A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6329438/
https://ncbi.nlm.nih.gov/pubmed/29514333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/pm/pny025
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