SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target

Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways potential therapeutic targets. Here, by exploring a lipid library, we show that AM580, a retinoid derivative and RAR-α agonist, is highly potent in i...

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Udgivet i:Nat Commun
Main Authors: Yuan, Shuofeng, Chu, Hin, Chan, Jasper Fuk-Woo, Ye, Zi-Wei, Wen, Lei, Yan, Bingpeng, Lai, Pok-Man, Tee, Kah-Meng, Huang, Jingjing, Chen, Dongdong, Li, Cun, Zhao, Xiaoyu, Yang, Dong, Chiu, Man Chun, Yip, Cyril, Poon, Vincent Kwok-Man, Chan, Chris Chung-Sing, Sze, Kong-Hung, Zhou, Jie, Chan, Ivy Hau-Yee, Kok, Kin-Hang, To, Kelvin Kai-Wang, Kao, Richard Yi-Tsun, Lau, Johnson Yiu-Nam, Jin, Dong-Yan, Perlman, Stanley, Yuen, Kwok-Yung
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328544/
https://ncbi.nlm.nih.gov/pubmed/30631056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-08015-x
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