Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility

Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Kaur, Amanpreet, Ecker, Brett L., Douglass, Stephen M., Kugel, Curtis H., Webster, Marie R., Almeida, Filipe V., Somasundaram, Rajasekharan, Hayden, James, Ban, Ehsan, Ahmadzadeh, Hossein, Franco-Barraza, Janusz, Shah, Neelima, Mellis, Ian A., Keeney, Frederick, Kossenkov, Andrew, Tang, Hsin-Yao, Yin, Xiangfan, Liu, Qin, Xu, Xiaowei, Fane, Mitchell, Brafford, Patricia, Herlyn, Meenhard, Speicher, David W., Wargo, Jennifer A., Tetzlaff, Michael T., Haydu, Lauren E., Raj, Arjun, Shenoy, Vivek, Cukierman, Edna, Weeraratna, Ashani T.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328333/
https://ncbi.nlm.nih.gov/pubmed/30279173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0193
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