Remodeling of the collagen matrix in aging skin promotes melanoma metastasis and affects immune cell motility

Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and...

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Détails bibliographiques
Publié dans:Cancer Discov
Auteurs principaux: Kaur, Amanpreet, Ecker, Brett L., Douglass, Stephen M., Kugel, Curtis H., Webster, Marie R., Almeida, Filipe V., Somasundaram, Rajasekharan, Hayden, James, Ban, Ehsan, Ahmadzadeh, Hossein, Franco-Barraza, Janusz, Shah, Neelima, Mellis, Ian A., Keeney, Frederick, Kossenkov, Andrew, Tang, Hsin-Yao, Yin, Xiangfan, Liu, Qin, Xu, Xiaowei, Fane, Mitchell, Brafford, Patricia, Herlyn, Meenhard, Speicher, David W., Wargo, Jennifer A., Tetzlaff, Michael T., Haydu, Lauren E., Raj, Arjun, Shenoy, Vivek, Cukierman, Edna, Weeraratna, Ashani T.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6328333/
https://ncbi.nlm.nih.gov/pubmed/30279173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0193
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