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IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells
In high-grade serous ovarian cancer (OC), chemotherapy eliminates the majority of tumor cells, leaving behind residual tumors enriched in OC stem cells (OCSC). OCSC, defined as aldehyde dehydrogenase–positive (ALDH(+)), persist and contribute to tumor relapse. Inflammatory cytokine IL-6 is elevated...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6328027/ https://ncbi.nlm.nih.gov/pubmed/30518684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122360 |
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