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Treatment of established TH2 cells with 4μ8c, an inhibitor of IRE1α, blocks IL-5 but not IL-4 secretion
BACKGROUND: T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1α), an activator of the unfolded protein response (UPR) pathway. Inhibition of IRE1α RNase activity in activated CD4(+) splenocytes from naïve mice, via treatment of the cells with the commercially...
Guardat en:
| Publicat a: | BMC Immunol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6327572/ https://ncbi.nlm.nih.gov/pubmed/30630412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-018-0283-7 |
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