Increased plasma neurofilament light chain concentration correlates with severity of post-mortem neurofibrillary tangle pathology and neurodegeneration

Alzheimer’s disease (AD) is pathologically characterized by the accumulation of amyloid-β (Aβ) plaques, neurofibrillary tangles and widespread neuronal loss in the brain. In recent years, blood biomarkers have emerged as a realistic prospect to highlight accumulating pathology for secondary preventi...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Ashton, Nicholas J., Leuzy, Antoine, Lim, Yau Mun, Troakes, Claire, Hortobágyi, Tibor, Höglund, Kina, Aarsland, Dag, Lovestone, Simon, Schöll, Michael, Blennow, Kaj, Zetterberg, Henrik, Hye, Abdul
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327431/
https://ncbi.nlm.nih.gov/pubmed/30626432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-018-0649-3
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