Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas

Cancer cells subvert host immune surveillance by altering immune checkpoint (IC) proteins. Some Epstein−Barr virus (EBV)-associated tumors have higher Programmed Cell Death Ligand, PD-L1 expression. However, it is not known how EBV alters ICs in the context of its preferred host, the B lymphocyte an...

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Publicado no:Leukemia
Main Authors: Anastasiadou, Eleni, Stroopinsky, Dina, Alimperti, Stella, Jiao, Alan L, Pyzer, Athalia R, Cippitelli, Claudia, Pepe, Giuseppina, Severa, Martina, Rosenblatt, Jacalyn, Etna, Marilena P, Rieger, Simone, Kempkes, Bettina, Coccia, Eliana M, Sui, Shannan J Ho, Chen, Christopher S, Uccini, Stefania, Avigan, David, Faggioni, Alberto, Trivedi, Pankaj, Slack, Frank J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6327052/
https://ncbi.nlm.nih.gov/pubmed/29946193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0178-x
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