טוען...

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

Squalene epoxidase (SQLE), also known as squalene monooxygenase, catalyzes the stereospecific conversion of squalene to 2,3(S)-oxidosqualene, a key step in cholesterol biosynthesis. SQLE inhibition is targeted for the treatment of hypercholesteremia, cancer, and fungal infections. However, lack of s...

תיאור מלא

שמור ב:

מידע ביבליוגרפי
הוצא לאור ב:	Nat Commun
Main Authors:	Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Publishing Group UK 2019
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6327030/ https://ncbi.nlm.nih.gov/pubmed/30626872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07928-x
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

פריטים דומים