VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages

Hyperactivation of the NLRP3 inflammasome contributes to the pathogenesis of multiple diseases, but the mechanisms underlying transcriptional regulation of Nlrp3 remain elusive. We demonstrate here that macrophages lacking V-set and immunoglobulin domain–containing 4 (Vsig4) exhibit significant incr...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Huang, Xiaoyong, Feng, Zeqing, Jiang, Yuanzhong, Li, Jialin, Xiang, Qun, Guo, Sheng, Yang, Chengying, Fei, Lei, Guo, Guoning, Zheng, Lixin, Wu, Yuzhang, Chen, Yongwen
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326752/
https://ncbi.nlm.nih.gov/pubmed/30662948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau7426
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