The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism, glycolysis and Rho-GDI/PTEN signaling: Implicating TIGAR in somatic resistance to endocrine therapy

Naturally-occurring somatic mutations in the estrogen receptor gene (ESR1) have been previously implicated in the clinical development of resistance to hormonal therapies, such as Tamoxifen. For example, the somatic mutation Y537S has been specifically associated with acquired endocrine resistance....

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Dades bibliogràfiques
Publicat a:Aging (Albany NY)
Autors principals: Fiorillo, Marco, Sanchez-Alvarez, Rosa, Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6326696/
https://ncbi.nlm.nih.gov/pubmed/30573703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.101690
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