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The Human IL-7 Receptor Gene: Deletions, Polymorphisms and Mutations
Most T cell subsets depend on IL-7 for survival. IL-7 binds to IL-7Rα and γc, initiating the signaling cascade. Deletion of IL-7Ra in humans has, for some time, been known to cause severe combined immunodeficiency. More recently, polymorphisms in IL-7R have been shown be a risk factor for a number o...
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| Publicado no: | Semin Immunol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6326362/ https://ncbi.nlm.nih.gov/pubmed/22425228 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2012.02.007 |
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