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Pharmacokinetic–Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation to investigate efficacy and safety. The appli...

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Bibliografiske detaljer
Udgivet i:Clin Pharmacokinet
Main Authors: Germovsek, Eva, Barker, Charlotte I. S., Sharland, Mike, Standing, Joseph F.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325987/
https://ncbi.nlm.nih.gov/pubmed/29675639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0659-0
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