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Pharmacokinetic–Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance

Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation to investigate efficacy and safety. The appli...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin Pharmacokinet
Prif Awduron: Germovsek, Eva, Barker, Charlotte I. S., Sharland, Mike, Standing, Joseph F.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer International Publishing 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325987/
https://ncbi.nlm.nih.gov/pubmed/29675639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40262-018-0659-0
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