A rare population of tumor antigen-specific CD4(+)CD8(+) double-positive αβ T lymphocytes uniquely provide CD8-independent TCR genes for engineering therapeutic T cells

BACKGROUND: High-affinity tumor antigen-specific T-cell receptor (TCR) gene is required to engineer potent T cells for therapeutic treatment of cancer patients. However, discovery of suitable therapeutic TCR genes is hampered by the fact that naturally occurring tumor antigen-specific TCRs are gener...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Matsuzaki, Junko, Tsuji, Takemasa, Chodon, Thinle, Ryan, Courtney, Koya, Richard C., Odunsi, Kunle
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325755/
https://ncbi.nlm.nih.gov/pubmed/30626427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-018-0467-y
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