HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma

BACKGROUND: HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. There are conflicting...

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Detalles Bibliográficos
Publicado en:BMC Cancer
Main Authors: Plum, Patrick Sven, Gebauer, Florian, Krämer, Max, Alakus, Hakan, Berlth, Felix, Chon, Seung-Hun, Schiffmann, Lars, Zander, Thomas, Büttner, Reinhard, Hölscher, Arnulf Heinrich, Bruns, Christiane Josephine, Quaas, Alexander, Loeser, Heike
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2019
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325716/
https://ncbi.nlm.nih.gov/pubmed/30621632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-5242-4
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