HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma

Abstract Background HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. There are con...

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Detalhes bibliográficos
Main Authors: Patrick Sven Plum, Florian Gebauer, Max Krämer, Hakan Alakus, Felix Berlth, Seung-Hun Chon, Lars Schiffmann, Thomas Zander, Reinhard Büttner, Arnulf Heinrich Hölscher, Christiane Josephine Bruns, Alexander Quaas, Heike Loeser
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-01-01
Colecção:BMC Cancer
Assuntos:
HER2/neu (ERBB2)
Esophageal adenocarcinoma (EAC)
Prognosis
Immunohistochemistry
Tissue microarray (TMA)
Fluorescence-in-situ-hybridization (FISH)
Acesso em linha:http://link.springer.com/article/10.1186/s12885-018-5242-4
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