Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence

Oesophageal cancer (OC) has high mortality. This study aims at determining the feasibility of liquid biopsies for genomic profiling in early stage OC, comparing two different technologies for mutational analysis in circulating cell -free DNA (ccfDNA) and evaluating the clinical impact of these somat...

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Udgivet i:Sci Rep
Main Authors: Pasternack, Helen, Fassunke, Jana, Plum, Patrick Sven, Chon, Seung-Hun, Hescheler, Daniel Alexander, Gassa, Asmae, Merkelbach-Bruse, Sabine, Bruns, Christiane Josephine, Perner, Sven, Hallek, Michael, Büttner, Reinhard, Bollschweiler, Elfriede, Hölscher, Arnulf Heinrich, Quaas, Alexander, Zander, Thomas, Weiss, Jonathan, Alakus, Hakan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6175817/
https://ncbi.nlm.nih.gov/pubmed/30297788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33027-4
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