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Pervasive Positive and Negative Feedback Regulation of Insulin-Like Signaling in Caenorhabditis elegans

The Caenorhabditis elegans insulin-like signaling network supports homeostasis and developmental plasticity. The genome encodes 40 insulin-like peptides and one known receptor. Feedback regulation has been reported, but the extent of feedback and its effect on signaling dynamics in response to chang...

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Pubblicato in:Genetics
Autori principali: Kaplan, Rebecca E. W., Maxwell, Colin S., Codd, Nicole Kurhanewicz, Baugh, L. Ryan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325697/
https://ncbi.nlm.nih.gov/pubmed/30425043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.118.301702
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