Voltage-Independent SK-Channel Dysfunction Causes Neuronal Hyperexcitability in the Hippocampus of Fmr1 Knock-Out Mice

Neuronal hyperexcitability is one of the major characteristics of fragile X syndrome (FXS), yet the molecular mechanisms of this critical dysfunction remain poorly understood. Here we report a major role of voltage-independent potassium (K(+))-channel dysfunction in hyperexcitability of CA3 pyramida...

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Vydáno v:J Neurosci
Hlavní autoři: Deng, Pan-Yue, Carlin, Dan, Oh, Young Mi, Myrick, Leila K., Warren, Stephen T., Cavalli, Valeria, Klyachko, Vitaly A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325266/
https://ncbi.nlm.nih.gov/pubmed/30389838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1593-18.2018
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