Identification of Functional MKK3/6 and MEK1/2 Homologs from Echinococcus granulosus and Investigation of Protoscolecidal Activity of Mitogen-Activated Protein Kinase Signaling Pathway Inhibitors In Vitro and In Vivo

Cystic echinococcosis is a zoonosis caused by the larval stage of Echinococcus granulosus sensu lato. There is an urgent need to develop new drugs for the treatment of this disease. In this study, we identified two new members of mitogen-activated protein kinase (MAPK) cascades, MKK3/6 and MEK1/2 ho...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Zhang, Chuanshan, Li, Jing, Aji, Tuerganaili, Li, Liang, Bi, Xiaojuan, Yang, Ning, Li, Zhide, Wang, Hui, Mao, Rui, Lü, Guodong, Shao, Yingmei, Vuitton, Dominique A., Wen, Hao, Lin, Renyong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325220/
https://ncbi.nlm.nih.gov/pubmed/30348669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01043-18
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