T-cell tolerance and exhaustion in the clearance of Echinococcus multilocularis: role of inoculum size in a quantitative hepatic experimental model

The local immune mechanisms responsible for either self-healing or sustained chronic infection are not clear, in the development of E. multilocularis larvae. Here, we developed a suitable experimental model that mimics naturally infected livers, according to the parasite load. We demonstrated that l...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhang, Chuanshan, Shao, Yingmei, Yang, Shuting, Bi, Xiaojuan, Li, Liang, Wang, Hui, Yang, Ning, Li, Zhide, Sun, Cheng, Lü, Guodong, Aji, Tuerganaili, Vuitton, Dominique A., Lin, Renyong, Wen, Hao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593833/
https://ncbi.nlm.nih.gov/pubmed/28894272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11703-1
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