Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4(+)T cells

The single and/or combination use of immune checkpoint blockade therapies in human infectious diseases and cancer are rapidly expanding. Despite early efforts, substantial uncertainty remains about the safety and efficacy of immune checkpoint blockade in some populations. Cytotoxic T-lymphocyte-asso...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Wang, Songcun, Chen, Chunqin, Li, Mengdie, Qian, Jinfeng, Sun, Fengyun, Li, Yunyun, Yu, Min, Wang, Mingyan, Zang, Xingxing, Zhu, Rui, Li, Dajin, Du, Meirong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325160/
https://ncbi.nlm.nih.gov/pubmed/30622243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1251-0
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