Direct therapeutic targeting of immune checkpoint PD-1 in pancreatic cancer

BACKGROUND: Pancreatic cancer (PC) hijacks innate cellular processes to promote cancer growth. We hypothesized that PC exploits PD-1/PD-L1 not only to avoid immune responses, but to directly enhance growth. We also hypothesized that immune checkpoint inhibitors (ICIs) have direct cytotoxicity in PC....

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Gao, Mei, Lin, Miranda, Moffitt, Richard A., Salazar, Marcela A., Park, Jinha, Vacirca, Jeffrey, Huang, Chuan, Shroyer, Kenneth R., Choi, Minsig, Georgakis, Georgios V., Sasson, Aaron R., Talamini, Mark A., Kim, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325157/
https://ncbi.nlm.nih.gov/pubmed/30377341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0298-0
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