Genome-wide profiling of adenine base editor specificity by EndoV-seq

The adenine base editor (ABE), capable of catalyzing A•T to G•C conversions, is an important gene editing toolbox. Here, we systematically evaluate genome-wide off-target deamination by ABEs using the EndoV-seq platform we developed. EndoV-seq utilizes Endonuclease V to nick the inosine-containing D...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Liang, Puping, Xie, Xiaowei, Zhi, Shengyao, Sun, Hongwei, Zhang, Xiya, Chen, Yu, Chen, Yuxi, Xiong, Yuanyan, Ma, Wenbin, Liu, Dan, Huang, Junjiu, Songyang, Zhou
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6325126/
https://ncbi.nlm.nih.gov/pubmed/30622278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07988-z
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