Combinatorial CRISPR/Cas9-approach to elucidate a far-upstream enhancer complex for tissue-specific Sox9 expression

SRY-box 9 (SOX9) is a master transcription factor that regulates cartilage development. SOX9 haploinsufficiency resulting from breakpoints in a ~1 Mb region upstream of SOX9 was reported in acampomelic campomelic dysplasia (ACD) patients, suggesting that essential enhancer regions of SOX9 for cartil...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Mochizuki, Yusuke, Chiba, Tomoki, Kataoka, Kensuke, Yamashita, Satoshi, Sato, Tempei, Kato, Tomomi, Takahashi, Kenji, Miyamoto, Takeshi, Kitazawa, Masashi, Hatta, Tomohisa, Natsume, Tohru, Takai, Shinro, Asahara, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324936/
https://ncbi.nlm.nih.gov/pubmed/30146478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2018.07.024
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