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Sex reversal following deletion of a single far upstream enhancer of Sox9
Cell fate decisions require appropriate regulation of key genes. Sox9, a direct target of SRY, is pivotal in mammalian sex determination. In vivo high-throughput chromatin accessibility techniques, transgenic assays, and genome editing revealed several novel gonadal regulatory elements in the 2 Mb g...
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| Publicado no: | Science |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6034650/ https://ncbi.nlm.nih.gov/pubmed/29903884 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aas9408 |
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