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Deletion of genes involved in the ketogluconate metabolism, Entner-Doudoroff pathway, and glucose dehydrogenase increase local and invasive virulence phenotypes in Streptococcus pneumoniae

Streptococcus pneumoniae displays increased resistance to antibiotic therapy following biofilm formation. A genome-wide search revealed that SP 0320 and SP 0675 (respectively annotated as 5-keto-D-gluconate-5-reductase and glucose dehydrogenase) contain the highest degree of homology to CsgA of Myxo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Hu, Fen Z., Król, Jarosław E., Tsai, Chen Hsuan Sherry, Eutsey, Rory A., Hiller, Luisa N., Sen, Bhaswati, Ahmed, Azad, Hillman, Todd, Buchinsky, Farrel J., Nistico, Laura, Dice, Bethany, Longwell, Mark, Horsey, Edward, Ehrlich, Garth D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324787/
https://ncbi.nlm.nih.gov/pubmed/30620734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209688
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