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Deletion of genes involved in the ketogluconate metabolism, Entner-Doudoroff pathway, and glucose dehydrogenase increase local and invasive virulence phenotypes in Streptococcus pneumoniae

Streptococcus pneumoniae displays increased resistance to antibiotic therapy following biofilm formation. A genome-wide search revealed that SP 0320 and SP 0675 (respectively annotated as 5-keto-D-gluconate-5-reductase and glucose dehydrogenase) contain the highest degree of homology to CsgA of Myxo...

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Publicado en:PLoS One
Autores principales: Hu, Fen Z., Król, Jarosław E., Tsai, Chen Hsuan Sherry, Eutsey, Rory A., Hiller, Luisa N., Sen, Bhaswati, Ahmed, Azad, Hillman, Todd, Buchinsky, Farrel J., Nistico, Laura, Dice, Bethany, Longwell, Mark, Horsey, Edward, Ehrlich, Garth D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324787/
https://ncbi.nlm.nih.gov/pubmed/30620734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0209688
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