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Conformational Intermediate That Controls KPC-2 Catalysis and Beta-Lactam Drug Resistance
The KPC-2 carbapenemase enzyme is responsible for drug resistance in the majority of carbapenem-resistant gram-negative bacterial infections in the United States. A better understanding of what permits KPC-2 to hydrolyze carbapenem antibiotics and how this might be inhibited is thus of fundamental i...
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| Publicado no: | ACS Catal |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6324736/ https://ncbi.nlm.nih.gov/pubmed/30637173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b03832 |
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