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Excess positional mutual information predicts both local and allosteric mutations affecting beta lactamase drug resistance
MOTIVATION: Bacterial resistance to antibiotics, particularly plasmid-encoded resistance to beta lactam drugs, poses an increasing threat to human health. Point mutations to beta-lactamase enzymes can greatly alter the level of resistance conferred, but predicting the effects of such mutations has b...
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| I publikationen: | Bioinformatics |
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| Huvudupphovsmän: | , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2016
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6078173/ https://ncbi.nlm.nih.gov/pubmed/27466622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btw492 |
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