Method development and validation of ursodiol and its major metabolites in human plasma by HPLC-tandem mass spectrometry

BACKGROUND: Ursodeoxycholic acid (UDCA) and its metabolites tauroursodeoxycholic acid (TUDCA) and glycoursodeoxycholic acid (GUDCA) have been the subject of several pharmacological studies. The objective of this study was to develop an innovative method of quantification by HPL-tandem mass spectrome...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol
Main Authors: Pinto, Márcio Cardoso, Berton, Danilo Chorfi, de Oliveira, Alexandre Cavenatti, Lazaro, Carolina Martins, Carandina, Silvana Aparecida Calafatti
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2019
Assuntos:
Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324612/
https://ncbi.nlm.nih.gov/pubmed/30655708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S187519
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