Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial

IMPORTANCE: Sepsis induces profound metabolic derangements, while exogenous levocarnitine mitigates metabolic dysfunction by enhancing glucose and lactate oxidation and increasing fatty acid shuttling. Previous trials in sepsis suggest beneficial effects of levocarnitine on patient-centered outcomes...

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Detalhes bibliográficos
Publicado no:JAMA Netw Open
Main Authors: Jones, Alan E., Puskarich, Michael A., Shapiro, Nathan I., Guirgis, Faheem W., Runyon, Michael, Adams, Jason Y., Sherwin, Robert, Arnold, Ryan, Roberts, Brian W., Kurz, Michael C., Wang, Henry E., Kline, Jeffrey A., Courtney, D. Mark, Trzeciak, Stephen, Sterling, Sarah A., Nandi, Utsav, Patki, Deepti, Viele, Kert
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324339/
https://ncbi.nlm.nih.gov/pubmed/30646314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.6076
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