Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial

IMPORTANCE: Sepsis induces profound metabolic derangements, while exogenous levocarnitine mitigates metabolic dysfunction by enhancing glucose and lactate oxidation and increasing fatty acid shuttling. Previous trials in sepsis suggest beneficial effects of levocarnitine on patient-centered outcomes...

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Detalles Bibliográficos
Publicado en:JAMA Netw Open
Main Authors: Jones, Alan E., Puskarich, Michael A., Shapiro, Nathan I., Guirgis, Faheem W., Runyon, Michael, Adams, Jason Y., Sherwin, Robert, Arnold, Ryan, Roberts, Brian W., Kurz, Michael C., Wang, Henry E., Kline, Jeffrey A., Courtney, D. Mark, Trzeciak, Stephen, Sterling, Sarah A., Nandi, Utsav, Patki, Deepti, Viele, Kert
Formato: Artigo
Idioma:Inglês
Publicado: American Medical Association 2018
Assuntos:
Original Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324339/
https://ncbi.nlm.nih.gov/pubmed/30646314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.6076
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