Effect of Levocarnitine vs Placebo as an Adjunctive Treatment for Septic Shock: The Rapid Administration of Carnitine in Sepsis (RACE) Randomized Clinical Trial

IMPORTANCE: Sepsis induces profound metabolic derangements, while exogenous levocarnitine mitigates metabolic dysfunction by enhancing glucose and lactate oxidation and increasing fatty acid shuttling. Previous trials in sepsis suggest beneficial effects of levocarnitine on patient-centered outcomes...

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Bibliografische gegevens
Gepubliceerd in:JAMA Netw Open
Hoofdauteurs: Jones, Alan E., Puskarich, Michael A., Shapiro, Nathan I., Guirgis, Faheem W., Runyon, Michael, Adams, Jason Y., Sherwin, Robert, Arnold, Ryan, Roberts, Brian W., Kurz, Michael C., Wang, Henry E., Kline, Jeffrey A., Courtney, D. Mark, Trzeciak, Stephen, Sterling, Sarah A., Nandi, Utsav, Patki, Deepti, Viele, Kert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Medical Association 2018
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Original Investigation
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324339/
https://ncbi.nlm.nih.gov/pubmed/30646314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.6076
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