Human Papillomavirus T-Cell Cross-reactivity in Cervical Cancer: Implications for Immunotherapy Clinical Trial Design

IMPORTANCE: Clinical trials are testing vaccines that target human papillomavirus 16 (HPV-16) oncoproteins for the treatment of cervical cancer regardless of the HPV type of the tumor. For patients with HPV-18–positive cancers, this strategy relies on cross-reactivity of HPV-16–reactive T cells agai...

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Publicat a:JAMA Netw Open
Autors principals: Helman, Sarah R., Stevanović, Sanja, Campbell, Tracy E., Kwong, Mei Li M., Doran, Stacey L., Faquin, William C., Hinrichs, Christian S.
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2018
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324313/
https://ncbi.nlm.nih.gov/pubmed/30646017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.0706
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