Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria

IMPORTANCE: Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. OBJECTIVE: To examine the associatio...

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Veröffentlicht in:JAMA Netw Open
Hauptverfasser: Baird, J. Kevin, Louisa, Melva, Noviyanti, Rintis, Ekawati, Lenny, Elyazar, Iqbal, Subekti, Decy, Chand, Krisin, Gayatri, Anggi, Instiaty, Soebianto, Saraswati, Crenna-Darusallam, Chelzie, Djoko, Dwi, Hasto, Bambang Dwi, Meriyenes, Dubel, Wesche, David, Nelwan, Erni J., Sutanto, Inge, Sudoyo, Herawati, Setiabudy, Rianto
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Medical Association 2018
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Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324265/
https://ncbi.nlm.nih.gov/pubmed/30646129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.1449
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