Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria

IMPORTANCE: Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. OBJECTIVE: To examine the associatio...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JAMA Netw Open
Päätekijät: Baird, J. Kevin, Louisa, Melva, Noviyanti, Rintis, Ekawati, Lenny, Elyazar, Iqbal, Subekti, Decy, Chand, Krisin, Gayatri, Anggi, Instiaty, Soebianto, Saraswati, Crenna-Darusallam, Chelzie, Djoko, Dwi, Hasto, Bambang Dwi, Meriyenes, Dubel, Wesche, David, Nelwan, Erni J., Sutanto, Inge, Sudoyo, Herawati, Setiabudy, Rianto
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Medical Association 2018
Aiheet:
Original Investigation
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6324265/
https://ncbi.nlm.nih.gov/pubmed/30646129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.1449
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