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Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria
IMPORTANCE: Latent hepatic Plasmodium vivax hypnozoites provoke repeated clinical attacks called relapses. Only primaquine phosphate kills hypnozoites, and its therapeutic activity may depend on naturally polymorphic cytochrome P450 2D6 isotype (CYP2D6) activity. OBJECTIVE: To examine the associatio...
Tallennettuna:
| Julkaisussa: | JAMA Netw Open |
|---|---|
| Päätekijät: | , , , , , , , , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Medical Association
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6324265/ https://ncbi.nlm.nih.gov/pubmed/30646129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamanetworkopen.2018.1449 |
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