The impact of the rs8005161 polymorphism on G protein-coupled receptor GPR65 (TDAG8) pH-associated activation in intestinal inflammation

BACKGROUND: Tissue inflammation in inflammatory bowel diseases (IBD) is associated with a decrease in local pH. The gene encoding G-protein-coupled receptor 65 (GPR65) has recently been reported to be a genetic risk factor for IBD. In response to extracellular acidification, proton activation of GPR...

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Detalhes bibliográficos
Publicado no:BMC Gastroenterol
Main Authors: Tcymbarevich, Irina V., Eloranta, Jyrki J., Rossel, Jean-Benoît, Obialo, Nicole, Spalinger, Marianne, Cosin-Roger, Jesus, Lang, Silvia, Kullak-Ublick, Gerd A., Wagner, Carsten A., Scharl, Michael, Seuwen, Klaus, Ruiz, Pedro A., Rogler, Gerhard, de Vallière, Cheryl, Misselwitz, Benjamin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323805/
https://ncbi.nlm.nih.gov/pubmed/30616622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12876-018-0922-8
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