Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate

BACKGROUND: Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood–retinal barrier (BRB) and blood–brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by whi...

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Détails bibliographiques
Publié dans:Fluids Barriers CNS
Auteurs principaux: Salameh, Therese S., Mortell, William G., Logsdon, Aric F., Butterfield, D. Allan, Banks, William A.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323732/
https://ncbi.nlm.nih.gov/pubmed/30616618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-018-0121-6
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