Disruption of the hippocampal and hypothalamic blood–brain barrier in a diet-induced obese model of type II diabetes: prevention and treatment by the mitochondrial carbonic anhydrase inhibitor, topiramate

BACKGROUND: Type II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood–retinal barrier (BRB) and blood–brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by whi...

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Vydáno v:Fluids Barriers CNS
Hlavní autoři: Salameh, Therese S., Mortell, William G., Logsdon, Aric F., Butterfield, D. Allan, Banks, William A.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323732/
https://ncbi.nlm.nih.gov/pubmed/30616618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-018-0121-6
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