Spt6 Association with RNA Polymerase II Directs mRNA Turnover During Transcription

Spt6 is an essential histone chaperone that mediates nucleosome reassembly during gene transcription. Spt6 also associates with RNA polymerase II (RNAPII) via a tandem Src2 homology domain. However, the significance of Spt6-RNAPII interaction is not well understood. Here, we show that Spt6 recruitme...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Dronamraju, Raghuvar, Hepperla, Austin J., Shibata, Yoichiro, Adams, Alexander T., Magnuson, Terry, Davis, Ian J., Strahl, Brian D.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6323640/
https://ncbi.nlm.nih.gov/pubmed/29932900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.020
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