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Effect of Protein-Protein Interactions and Solvent Viscosity on the Rotational Diffusion of Proteins in Crowded Environments

The rotational diffusion of a protein in the presence of protein crowder molecules was analyzed via computer simulations. Cluster formation as a result of transient intermolecular contacts was identified as the dominant effect for reduced rotational diffusion upon crowding. The slow-down in diffusio...

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Publicat a:Phys Chem Chem Phys
Autors principals: Nawrocki, Grzegorz, Karaboga, Alp, Sugita, Yuji, Feig, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322922/
https://ncbi.nlm.nih.gov/pubmed/30560249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8cp06142d
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