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Reduced native state stability in crowded cellular environment due to protein-protein interactions

The effect of cellular crowding environments on protein structure and stability is a key issue in molecular and cellular biology. The classical view of crowding emphasizes the volume exclusion effect that generally favors compact, native states. Here, results from molecular dynamics simulations and...

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Bibliografski detalji
Glavni autori: Harada, Ryuhei, Tochio, Naoya, Kigawa, Takanori, Sugita, Yuji, Feig, Michael
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601481/
https://ncbi.nlm.nih.gov/pubmed/23402619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3126992
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