Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus

Mutations in the genes encoding nuclear factor (erythroid-derived 2)-like 2 (NRF2), Kelch-like ECH-associated protein 1 (KEAP1), and cullin 3 (CUL3) are commonly observed in human esophageal squamous cell carcinoma (ESCC) and result in activation of the NRF2 signaling pathway. Moreover, hyperactivit...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Fu, Junsheng, Xiong, Zhaohui, Huang, Caizhi, Li, Jing, Yang, Wenjun, Han, Yuning, Paiboonrungruan, Chorlada, Major, Michael B., Chen, Ke-Neng, Kang, Xiaozheng, Chen, Xiaoxin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6322899/
https://ncbi.nlm.nih.gov/pubmed/30409900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005963
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